NE 162 - Radiation Biophysics and Dosimetry
Spring 2008
Lectures: Prof. Jasmina Vujic
Tu 5:00-6:30 pm, 71 Evans ; Th 5:00-6:30 pm, 1171 Etcheverry Hall
GSI: JONATHAN DREYER, jdreyer@berkeley.edu
Office Hours: TBD
Room: TBD
NE 162 - Radiation Biophysics and Dosimetry
Spring 2008
Lectures: Prof. Jasmina Vujic
Tu 5:00-6:30 pm, 71 Evans ; Th 5:00-6:30 pm, 1171 Etcheverry Hall
| Lecture | date | Topic | Chapter in Textbook | |
| 1 | Jan 22 |
Introduction. History of radiation. Atoms, elements, isotopes, atomic structure, atomic models, energy levels in an atom, excitation and ionization of an atom. | Ch 1, Ch 2 Notes 1 |
|
| 2 | Jan 24 |
Nuclear structure. Nuclear force. Binding energy. Q-Value in nuclear reactions. Energy levels in the nucleus. | Ch 3 Notes 2 |
|
| 3 | Jan 29 |
Radioactivity. Types of radioactive decay. Radioactive decay schemes. Energy released per decay. Law of radioactive decay. Activity and specific activity. Radioactive decay chains. | Ch 3, Ch 4 Notes 3 |
|
| 4 | Jan 31 |
Natural and man-made sources of radiation. X-ray sources. Ion sources. | Ch 1-4, (Shultis Ch 4) Notes 4 |
|
| 5 | Feb 5 |
Interaction of photons with matter. Attenuation and absorption coefficients. | Ch 8 Notes 5 Homework 1 due |
|
| 6 | Feb 7 |
Interaction of photons with matter. Attenuation and absorption coefficients. | Ch 8 | |
| 7 | Feb 12 |
Interaction of heavy charged particles with matter. | Ch 5 Notes 7 Homework 2 due |
|
| 8 | Feb 14 |
Interaction of electrons with matter. Phenomena associated with charged particles tracks. | Ch 6, Ch 7 Notes 8 |
|
| 9 | Feb 19 |
Neutron sources and interaction of neutrons with matter. | Ch 9 Notes 9 Homework 3 due |
|
| 10 | Feb 21 |
Neutron sources and interaction of neutrons with matter. | Ch 9 Notes 10 |
|
| 11 |
Feb 26 | Methods of radiation detection I |
Ch 10 Notes 11 |
|
| 12 | Feb 28 | Review and examples |
Ch 1-9 (GSI) |
|
| 13 |
March 4 |
MIDTERM I |
Ch 1-9, Notes (GSI) | |
| 14 |
March 6 |
Monte Carlo methods for radiation transport calculations. Sampling and scoring techniques in MC. Sample analog MC calculation. Tallies. Error analysis. | Intro to MC |
|
| 15 |
March 11 |
Introduction to the MCNP Monte Carlo code. | MCNP
Manual |
|
| 16 |
March 13 |
Introduction to the MCNP Monte Carlo code. | Running MCNP on DECF computers |
|
| 17 | March 18 |
Characterization of radiation sources, fields, and energy transfer mechanisms. Kerma, absorbed dose and LET. | Notes11
(Shultis Ch 2 and 5.1, Faw Ch 1.3) Notes 11a Homework 4 due |
|
| 18 | March 20 |
Concept of radiation response functions. Response functions
for photons and neutrons. Basic methods for external radiation dose calculations.
Uncollided radiation dose from a point source. |
Ch 12, Notes (Shultis Ch 5.3-5.8) (Shultis Ch 6.1, Faw
Ch 6.5) Notes11b |
|
| - |
March 25 |
SPRING BREAK |
||
| - |
March 27 |
SRING BREAK |
||
| 19 | April 1 | Uncollided radiation dose from distributed sources. Point-kernel concept
for total dose. |
Ch 12, Notes (Shultis 6.2-6.3,
Faw Ch 6.5) Homework 5 due |
|
| 20 |
April 3 |
The human cell. Structure of DNA. Chromosomes and genetic information. Cell division. Radiation chemistry of aqueous solutions. Radiation chemistry of DNA solutions.Biological effects of radiation. | Ch 13 (Alpen Ch 6, Faw Ch 3) Notes12a Notes 12 |
|
| 21 |
April 8 |
Theories and models for cell survival. Survival curve and its significance. Modification of radiation response.Dose-response relationships. Target theory and the linear-quadratic model. Effects of high doses of radiation: stochastic and non-stochastic | Ch 13 (Alpen Ch 8 and 9) Ch 13, (Alpen Ch 11 and 12, Faw Ch 3.4) Notes 13 Homework 6 due |
|
| 22 |
April 10 |
Radiation carcinogenesis and genetic effects. Measures
of risk from low-level exposure. Exposure standards and limits. Exposure to natural and man-made sources. Special techniques for external electron dose. |
Ch 14, (Faw 1.4, 3.7, 4 and 5) Notes14a Ch 15, Notes (Shultis Ch 9, Faw Ch 7) Notes 14 |
|
| 23 |
April 15 |
Special techniques for external photon dose: buldup factors, albedo
concept. Biomedical application of radiation: Medical Imaging and Cancer Therapy |
-Ch 15, Notes (Shultis Ch 7, Faw Ch 6.6)(Shultis Ch 8, Faw Ch 6.7)
Buildup Factors, Table
of Coefficients, BNCT |
|
| 24 | April 17 |
Review | Ch 10, 12 -15 |
|
| 25 | April 22 |
MIDTERM II | Ch 10, 12 -15 | |
| 26 | April 24 |
The Effect of Cosmic Radiation on Humans |
Dr Sylvain Costes, LBNL Notes 16 (Spring 2007 Notes) Notes 16 (Spring 2008 Notes) | |
| 27 | April 29 | The general method for internal dose evaluation. Source-organ transformation models. The ICRP models for the respiratory and GI systems. The ICRP recommendations for exposure limits. | Ch 16,
(Faw 8.1- 8.3)(Faw 8.4, 8.7-8.8)(Faw 8.12) Homework
9 Help Homework 8 due |
|
| 28 | May 1 |
Simulation of dose distribution in MIRD phantom by MCNP | ||
| 29 | May 6 |
Shielding calculations using MCNP | Notes | |
| 30 | May 8 |
REVIEW | Homework 9 due | |
| May 21 | 17:00-20:00 Final Exam | 3102 Etcheverry |